期刊
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
卷 22, 期 5, 页码 499-508出版社
JAPAN ATHEROSCLEROSIS SOC
DOI: 10.5551/jat.26450
关键词
Lectin-like oxidized low-density lipoprotein receptor-1; LOX-1 ligand containing ApoB; Cardio-ankle vascular index; Community-based study
资金
- Regional Innovation Cluster Program, Global Type, Ministry of Education, Culture, Sports, Science and Technology
- Researchers, Hyogo College Medicine
- Japan Society for the Promotion of Science [23790711, B 21390211, B 23390178, C 23590835, C25460778]
- Intramural Research Fund of the National Cerebral and Cardiovascular Center [22-4-5]
Aims: Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 ligands containing apolipoprotein B (LAB) and lectin-like oxidized LDL receptor-1 (LOX-1) are known as LOX-1-related modified LDL indicators. These indicators play an important role in the early phase atherosclerosis, but the relationship between these indicators and subclinical atherosclerosis, as represented by the cardio-ankle vascular index (CAVI), has not been assessed. We herein investigated the association of LOX-1-related modified LDL indicators and the CAVI in healthy, Japanese urban community inhabitants who were considered to be at low risk for cardiovascular disease (CVD). Methods: The participants were 515 healthy Japanese (310 men and 205 women) without a history of CVD, cancer or the use of medication for hypertension, diabetes or dyslipidaemia. To estimate the association between LOX-1-related modified LDL indicators (LAB, soluble form of LOX-1 (sLOX-1)) and the CAVI, we performed multivariable linear regression analyses with possible confounders such as the serum LDL cholesterol level. Results: The plasma LAB showed a positive association with the CAVI in men (standardized coefficient: 0.11, p=0.04). This relationship was not observed in women. On the other hand, no clear association was observed between the CAVI and the plasma sLOX-1 level in either sex. Conclusions: The plasma LAB levels may represent a useful marker for detecting potential atherosclerosis in healthy individuals considered to be at low risk for atherosclerosis and CVD. Further studies are needed to confirm the present findings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据