Facile nitroxide-mediated oxidations of D-glucose to D-glucaric acid

The oxidation of D-( +)-glucose to D-glucaric acid using the TEMPO-like nitroxide oxidation catalyst, 4-acetamido-2,2,6,6-tetramethyl-l-piperidinyloxy (4-acetamido-TEMPO) was carried out using several oxidizing agents and co-catalyst. The pH and temperature of the reactions were closely monitored to decrease degradations during the oxidation, and several isolation methods were explored. (C) 2001 Elsevier Science Ltd. All rights reserved.