期刊
CLINICAL IMMUNOLOGY
卷 101, 期 2, 页码 237-247出版社
ACADEMIC PRESS INC
DOI: 10.1006/clim.2001.5109
关键词
EIAV; lentivirus; equine; adoptive transfer; SCID; CTL; lymphocyte engraftment
类别
资金
- NIAID NIH HHS [AI 24291, K08 AI001575, AI 44638, AI 01575] Funding Source: Medline
Acute infection with equine infectious anemia virus (EIAV), a lentivirus of horses, results in a persistent high-level viremia in Arabian foals affected with severe combined immunodeficiency (SCID). This observation argues against the idea that the transient nature of acute lentiviral viremia is solely a function of viral population dynamics. To extend these studies, EIAV-specific immune reconstitution was attempted prior to EIAV challenge in two SCID foals, using adoptively transferred virus-stimulated lymphocytes derived from persistently EIAV-infected half sibling donors. Following transfer, lymphocyte engraftment occurred in one foal, and EIAV-specific cytotoxic T lymphocytes as well as neutralizing antibody activity developed. Following a brief period of plasma viremia in this foal, EIAV replication was controlled and plasma virus could not be detected by RT-PCR or culture. These results provide further direct evidence that a specific immune response is required for termination of plasma viremia in acute lentiviral infections. (C) 2001 Academic Press.
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