Inhibition of ganciclovir-susceptible and -resistant human cytomegalovirus clinical isolates by the benzimidazole L-riboside 1263W94

The average 50% inhibitory concentration (IC50) values for AD169 were 0.22 +/- 0.09 muM 1263W94 and 5.36 +/- 0.12 muM ganciclovir. For 35 human cytomegalovirus (HCMV) clinical isolates the average IC50 was 0.42 +/- 0.09 muM 1263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the average IC50 was 3.78 +/- 1.62 muM ganciclovir. Nine HCMV clinical isolates: that were resistant to ganciclovir were completely susceptible to 1263W94.