期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 24, 期 11, 页码 1286-1289出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.24.1286
关键词
steroidal saponin; cytotoxic activity; HL-60 cell; structure-activity relationship
We have systematically examined the cytotoxic activities of the steroidal saponins mainly isolated from the Liliaceae plants against HL-60 human promyelocytic leukemia cells and found several structure-activity relationships. Some steroidal saponins evaluated in the assay system showed considerable cytotoxic activities, which were almost as potent as that of etoposide used as a positive control. The activities were found to be sensitive to the monosaccharides constituting the sugar moieties and their sequences, as well as to the structures of the aglycons.
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