期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 49, 期 11, 页码 1406-1411出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.49.1406
关键词
delavirdine analogue; arylpyrrole motif synthesis; anti-human immunodeficiency virus (HIV) activity
In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.
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