期刊
AVIAN DISEASES
卷 55, 期 4, 页码 724-727出版社
AMER ASSOC AVIAN PATHOLOGISTS
DOI: 10.1637/9774-050911-Case.1
关键词
avian influenza; influenza A virus; H9N2; chicken; minor poultry
资金
- National Veterinary Research and Quarantine Service of Korea [Z-AD15-2007-08-03]
- Ministry for Food, Agriculture, Forestry & Fisheries (MAFRA), Republic of Korea [Z-AD15-2007-08-03] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
An outbreak of avian influenza, caused by an H9N2 low-pathogenic avian influenza virus (AIV), occurred in a chicken farm and caused severe economic losses due to mortality and diarrhea. AIV was isolated and identified in a sample from an affected native Korean chicken. Genetic analysis of the isolate revealed a high sequence similarity to genes of novel reassortant H9N2 viruses isolated from slaughterhouses and live bird markets in Korea in 2008 and 2009. Animal challenge studies demonstrated that the replication kinetics and pathogenicity of the isolate were considerably altered due to adaptation in chickens. Vaccine protection studies indicated that commercial vaccine was not able to prevent virus shedding and clinical disease when chickens were challenged with the isolate. These results suggest that the novel H9N2 virus possesses the capacity to replicate efficiently in the respiratory system against vaccination and to cause severe disease in domestic chickens. The results also highlight the importance of appropriate updating of vaccine strains, based on continuous surveillance data, to prevent the possibility of a new H9N2 epidemic in Korea.
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