期刊
BLOOD CELLS MOLECULES AND DISEASES
卷 27, 期 6, 页码 1000-1004出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/bcmd.2001.0473
关键词
-
类别
Leukocyte adhesion deficiency (LAD) is an immunodeficiency caused by defects in the adhesion of leukocytes (especially neutrophils) to the blood vessel wall. As a result, patients with LAD suffer from severe bacterial infections and impaired wound healing. In LAD-1, mutations are found in INTG2, the gene that encodes the beta subunit of the beta(2) integrins. In the rare LAD-II disease, the fucosylation of selectin ligands is disturbed, caused by mutations in the gene for a GDP-fucose transporter of the Golgi. This article summarizes all known patient mutations and polymorphisms in these genes. (C) 2001 Elsevier Science.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据