期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 39, 期 3, 页码 188-198出版社
JOHN WILEY & SONS INC
DOI: 10.1002/dev.1044
关键词
opioids; shock conditioning; olfactory learning; consolidation; infant rats; naltrexone; sensitive period
资金
- NICHD NIH HHS [HD 33402, R01 HD033402] Funding Source: Medline
- NIDA NIH HHS [1F31 DA06082-01, F31 DA006082] Funding Source: Medline
We assessed the neurochemical basis of olfactory learning induced by presentations of odor and moderate shock in infant rats. paradoxically, shock conditioning produces an odor preference in 8-day-olds, but an odor aversion in 12-day-olds. Studies have demonstrated the importance of opioids in early olfactory, learning; their specific role remains undefined. In this study, postnatal Days 8 and 12 pups it,ere systemically injected with naltrexone, a nonspecific opioid antagonist, or saline and received either paired or backward presentations of odor-moderate shock or odor-only presentations. Blocking the opioid system during Conditioning disrupted acquisition of the Day 8 odor preference, but not the Day 12 odor aversion. Additional Day 8 pups were given naltrexone posttraining. Naltrexone not only blocked consolidation of an odor preference but also yielded an odor aversion. These results suggest that the opioid system has a critical role in both olfactory learning and consolidation of odor preferences during the sensitive period. (C) 2001 John Wiley & Sons, Inc.
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