期刊
BEHAVIOURAL PHARMACOLOGY
卷 12, 期 6-7, 页码 451-460出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008877-200111000-00005
关键词
anxiolytics; benzodiazepines; serotonin; genetic; knockout mice; inbred mice; selected lines
Anxiolytic drugs exert their pharmacological actions by binding to molecular targets, such as benzodiazepine receptors or 5-hydroxytryptamine (5-HT) receptors. Specific genes encode these receptors, or the subunits of which they are formed. Therefore, genetic factors may influence strongly the ability of anti-anxiety agents to produce their behavioural effects. The literature on this subject is reviewed here, with emphasis on data derived from studies with rodents. We present in a critical way the animal models used in the studies aimed at investigating the genetic basis of the action of anxiolytic compounds, including inbred mice, selected lines, linkage strains or mice generated by targeted mutation. Data show that increased anxiety-like behaviour is not a predictive factor for increased sensitivity to anxiolytic treatment, and it is possible that gene deletion might not be isomorphic to pharmacological antagonism. It is suggested that the strain differences in anxiety-like behaviour may be used as a tool in assaying anxiolytic activity of new drugs. (C) 2001 Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据