期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 45, 期 11, 页码 3198-3201出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.45.11.3198-3201.2001
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We found that an extract of Aretostaphylos uva-ursi markedly reduced the MICs of beta -lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various beta -lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.
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