期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 45, 期 5, 页码 S158-S167出版社
MOSBY-ELSEVIER
DOI: 10.1067/mjd.2001.113718
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Retinoids are small vitamin A-derived lipophilic compounds that influence a wide variety of developmental and metabolic processes. Retinoids exert their action by activating transcription factors belonging to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) subfamilies of nuclear receptors. Therapeutically, retinoids are used for the treatment of dermatological disorders and certain cancers. Dyslipidemia is a common side-effect of therapy with the currently available retinoids. This review summarizes our current understanding of the molecular mechanisms of regulation of lipid and lipoprotein metabolism by retinoids.
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