A new total synthesis of the marine tunicate alkaloid lepadiformine

[GRAPHICS] A total synthesis of racemic lepadiformine has been achieved via a route that utilizes as key steps a novel stereocontrolled intramolecular spirocyclization of an allyisilane/N-acyliminium ion and the application of our radical-based methodology for production of N-acylimines from o-aminobenzamides.