期刊
AUTOPHAGY
卷 10, 期 4, 页码 556-561出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.27280
关键词
histone posttranslational modifications; histone code; HAT; HDAC; HDM; HMT; KAT8; hMOF; MYST1; EHMT2; G9a; SUV420H2
类别
资金
- Swedish Childhood Cancer Foundation
- Swedish Cancer Society
- Swedish Research Council
- Cancer Society in Stockholm
- Karolinska Institutet Foundations
Modifications of histones, the chief protein components of the chromatin, have emerged as critical regulators of life and death. While the apoptotic histone code came to light a few years ago, accumulating evidence indicates that autophagy, a cell survival pathway, is also heavily regulated by histone-modifying proteins. In this review we describe the emerging autophagic histone code and the role of histone modifications in the cellular life vs. death decision.
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