期刊
AUTOPHAGY
卷 9, 期 10, 页码 1621-1623出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.25803
关键词
autophagic flux; cell death; histone H4 lysine 16 acetylation (H4K16ac); hMOF; KAT8; MYST1; SIRT1
类别
资金
- NIGMS NIH HHS [R01 GM053396] Funding Source: Medline
Autophagy is an evolutionarily conserved process in eukaryotes by which cytoplasmic components including macromolecules and organelles are degraded by the lysosome/vacuole. Autophagy is implicated in a number of physiological processes important for human health and disease. Although primarily cytoprotective, autophagy can also contribute to cell death; it is thus important to understand what distinguishes the life or death decision in autophagic cells. Despite the fact that the execution of autophagy includes a unique set of cytoplasmic events, nuclear events, in particular transcriptional programs, have emerged as an important regulator of this process. In addition, a critical linkage was recently unveiled between specific histone posttranslational modifications and the transcriptional regulation of autophagy-related genes, which initiates a regulatory feedback loop, and serves as a key determinant of survival versus death responses upon autophagy induction.
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