期刊
AUTOPHAGY
卷 9, 期 12, 页码 1975-1982出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.26152
关键词
autophagy; apoptosis; genotoxic stress; C; elegans
类别
资金
- National Basic Research Program of China [2013CB910100, 2011CB910100]
- National Natural Science Foundation of China [31225018]
- Howard Hughes Medical Institute
The physiological relationship between autophagy and programmed cell death during C. elegans development is poorly understood. In C. elegans, 131 somatic cells and a large number of germline cells undergo programmed cell death. Autophagy genes function in the removal of somatic cell corpses during embryogenesis. Here we demonstrated that autophagy activity participates in germ-cell death induced by genotoxic stress. Upon ray treatment, fewer germline cells execute the death program in autophagy mutants. Autophagy also contributes to physiological germ-cell death and post-embryonic cell death in ventral cord neurons when ced-3 caspase activity is partially compromised. Our study reveals that autophagy activity contributes to programmed cell death during C. elegans development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据