期刊
AUTOPHAGY
卷 9, 期 6, 页码 819-829出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.23908
关键词
acetylation; deacetylation; lysine; autophagy; FOXO; ATG genes; post-translational modification; protein aggregates; Huntington disease
类别
资金
- CNRS
- Aix-Marseille Universite
- CEFIPRA
- FRM
- ANR
- ARC
Autophagy is an evolutionarily conserved catabolic process through which different components of the cells are sequestered into double-membrane cytosolic vesicles called autophagosomes, and fated to degradation through fusion with lysosomes. Autophagy plays a major function in many physiological processes including response to different stress factors, energy homeostasis, elimination of cellular organelles and tissue remodeling during development. Consequently, autophagy is strictly controlled and post-translational modifications such as phosphorylation and ubiquitination have long been associated with autophagy regulation. In contrast, the importance of acetylation in autophagy control has only emerged in the last few years. In this review, we summarize how previously identified histone acetylases and deacetylases modify key autophagic effector proteins, and discuss how this has an impact on physiological and pathological cellular processes.
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