期刊
AUTOPHAGY
卷 10, 期 1, 页码 1-2出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.27242
关键词
autophagosome; autophagy; ER-Golgi intermediate compartment; LC3; lysosome; stress
类别
资金
- NIGMS NIH HHS [R01 GM053396, GM053396] Funding Source: Medline
How does the phagophore form? Which membrane acts as a platform for its biogenesis? Over the years, extensive use of microscopy techniques have led to the controversial identification of multiple potential membranes as precursors for phagophore nucleation and/or for the supply of lipids to the expanding compartment. Nevertheless, none of these studies has established a direct functional link between membrane sources and autophagosome biogenesis. Addressing this point, in a recent study highlighted by a punctum in this issue, Ge and coworkers developed an in vitro approach to determine the identity of the membranes responsible for the lipidation of LC3, thus identifying the ER-Golgi intermediate compartment (ERGIC) as a potential key determinant of phagophore biogenesis.
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