期刊
AUTOPHAGY
卷 8, 期 1, 页码 6-17出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.8.1.16645
关键词
autophagy; Atg6; Beclin 1; Bcl-2; membrane trafficking
类别
资金
- Flanders Institute for Biotechnology
- EC RTD Integrated Project [MRTN-CT-035624]
- Belgian grants (Interuniversity Attraction Poles) [IAP 6/18]
- Fonds Wetenschappelijk Onderzoek Vlaanderen, FWO [FWO G.0875.11, FWO G.0973.11]
- Ghent University [BOF 2001-GOA 12050502, BOF 2005-GOA 01GC0205]
- Ministry of University and Research [RF07.103]
- Ministry for Health [ONC-ORD 35/07]
- Flemish Government [BOF09/01M00709]
- Flemish Government-Methusalem [BOF09/01M00709]
Beclin 1 (Atg6) is a well-known key regulator of autophagy. Although Beclin 1 is enzymatically inert, it governs the autophagic process by regulating PtdIns3KC3-dependent generation of phosphatidylinositol 3-phosphate (PtdIns(3) P) and the subsequent recruitment of additional Atg proteins that orchestrate autophagosome formation. Furthermore, Beclin 1 is implicated in numerous biological processes, including adaptation to stress, development, endocytosis, cytokinesis, immunity, tumorigenesis, aging and cell death. Whether all of these processes involve only the autophagy-inducing function of Beclin 1 is now being seriously questioned, because Beclin 1 appears to exercise several non-autophagy functions. Therefore, we should broaden our view of Beclin 1 as a specialized molecule in autophagy to that of a multifunctional protein. The central role of Beclin 1 in multiple signaling events obviously requires tight regulation at multiple levels. Its function is kept in check by diverse mechanisms, such as epigenetic silencing, microRNA regulation, post-translational modifications, and protein-protein interactions. Interestingly, multiple diseases are associated with deficiency or malfunction of Beclin 1, which makes it a potentially valuable target for various therapies, including anticancer treatment. In this review, we focus on Beclin 1 as a multifunctional protein, discuss the variety of mechanisms by which it is controlled, and give an overview of Beclin 1-associated pathologies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据