期刊
AUTOPHAGY
卷 8, 期 9, 页码 1286-1299出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.21212
关键词
autoimmune disease; autoinflammatory disease; autophagy; immunity
类别
资金
- Major State Basic Research Development Program of China (973 program) [2012CB517700]
- National Natural Science Foundation of China [30825021]
- Natural Science Fund of China [81021004]
Autophagy is now emerging as a spotlight in trafficking events that activate innate and adaptive immunity. It facilitates innate pathogen detection and antigen presentation, as well as pathogen clearance and lymphocyte homeostasis. In this review, we first summarize new insights into its functions in immunity, which underlie its associations with autoimmunity. As some lines of evidence are emerging to support its role in autoimmune and autoinflammatory diseases, we further discuss whether and how it affects autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus and multiple sclerosis, as well as autoinflammatory diseases, such as Crohn disease and vitiligo.
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