期刊
AUTOPHAGY
卷 8, 期 5, 页码 858-860出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.20055
关键词
autophagosome; lysosome; dynein; axonal transport; neurodegeneration
类别
资金
- NINDS NIH HHS [R01 NS060698, NS060698, R37 NS060698] Funding Source: Medline
Autophagy is an essential lysosomal degradation pathway in neurons, yet the basic mechanisms involved are poorly understood. Here, we discuss our recent study in which we define autophagosome dynamics in primary neurons. We find that autophagosomes initiate at the distal tip of the axon in primary neurons and undergo retrograde transport toward the cell soma. As they move distally to proximally along the axon, autophagosomes mature and become increasingly acidified, consistent with the formation of an autolysosomal compartment that may more effectively catalyze the degradation of enveloped cargo. Our findings suggest that autophagosome biogenesis and maturation is a constitutive process in primary neurons that is temporally and spatially regulated along the axon.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据