期刊
AUTOPHAGY
卷 8, 期 7, 页码 1009-1031出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.19821
关键词
autophagy; kidney; acute kidney injury; aging; polycystic kidney disease; podocyte; glomerulus; kidney transplantation; mTOR
类别
资金
- Deutsche Forschungsgemeinschaft [KFO 201]
- Excellence Initiative of the German Federal and State Governments [EXC 294]
- GerontosysII-NephAge [031589GA]
- U.S. National Institutes of Health [RO1DK056851, DK074835, DK058831, DK087843, DK083491]
- U.S. Veterans Administration
- Ministry of Health, Labour and Welfare of Japan
- KAKENHI [21591148, 00452235]
- Grants-in-Aid for Scientific Research [21591148, 23890085] Funding Source: KAKEN
Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.
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