期刊
AUTOPHAGY
卷 8, 期 6, 页码 992-994出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.20285
关键词
MTOR; autophagy; energy metabolism; mitochondrial biogenesis; apoptosis; metabolic syndrome
类别
资金
- NHLBI NIH HHS [HL77131, HL085307, P01 HL085307, R01 HL077131] Funding Source: Medline
- NIDDK NIH HHS [R01 DK073608, DK73608] Funding Source: Medline
Autophagy represents an evolutionarily conserved catabolic mechanism that promotes cell survival by releasing energy substrates via degradation of cellular constituents and by eliminating defective organelles under conditions of stress, such as starvation and hypoxia. The link between enhanced autophagy and nutrient deprivation has been well established. For example, chronic myocardial ischemia, a condition of insufficient oxygen and nutrition, activates autophagy to degrade and recycle damaged cellular structures, thereby ameliorating cardiomyocyte injury.
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