期刊
AUTOPHAGY
卷 7, 期 3, 页码 297-300出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.7.3.14502
关键词
Atg; autophagy-related; Cvt; cytoplasm to vacuole targeting; PAS; phagophore assembly site
类别
资金
- NIGMS NIH HHS [R01 GM053396] Funding Source: Medline
Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging. Maintaining a healthy population of mitochondria is thus essential for proper cellular homeostasis. Several strategies have evolved to prevent and limit mitochondria damage, and macroautophagy plays a role in degrading superfluous or severely damaged mitochondria. Selective removal of mitochondria by autophagy (termed mitophagy) has been extensively studied recently in both yeast and mammalian cells. In this review, we summarize our current knowledge of mitophagy. We also compare the molecular process of mitophagy with other types of specific autophagic pathways and discuss its biological importance.
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