Resistance of T-cell receptor 8-chain-deficient mice to experimental Candida albicans vaginitis

Conditions consistent with tolerance or immunoregulation have been observed in experimental Candida albicans vaginal infections. The present study investigated the role of gamma/delta T cells in experimental vaginal candidiasis. Results showed that T-cell receptor delta -chain-knockout mice had significantly less vaginal fungal burden when compared to wild-type mice, suggesting an immunoregulatoty role for gamma/delta T cells in Candida vaginitis.