期刊
AUTOPHAGY
卷 7, 期 3, 页码 315-320出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.7.3.14044
关键词
sepsis; tumor necrosis factoralpha; RAW 264.7; peritoneal macrophages
类别
资金
- NIGMS NIH HHS [R01 GM082830] Funding Source: Medline
Toll-like receptor (TLR) signaling is an important part of the innate immune response. One of the downstream responses to TLR4 signaling upon lipopolysaccharide (LPS) stimulation is the induction of autophagy, which is a key response to multiple stressors. An additional adaptive signaling molecule that is involved in the response to stress is heme oxygenase-1 (HO-1). HO-1 signaling is essential to limit inflammation and restore homeostasis. We found that LPS induced autophagic signaling in macrophages via a TLR4, HO-1 dependent pathway in macrophages. These data add to the developing contribution of autophagic signaling as part of the inflammatory response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据