期刊
AUTOPHAGY
卷 6, 期 5, 页码 670-671出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.6.5.12434
关键词
metformin; 2 deoxyglucose; prostate cancer; metabolism; AMPK; apoptosis; autophagy; p53
类别
Targeting cancer cell metabolism is a promising new strategy to fight cancer. Metformin, a widely used antidiabetic agent, and 2-deoxyglucose (2DG) drastically affect cancer cell metabolism. Recently, we showed that the combination of the two drugs was much more harmful for cancer cells than the treatment with metformin or 2DG alone. At the cellular level, this combination leads to p53- and AMPK-dependent apoptosis. Furthermore, we showed that metformin inhibits 2DG-induced autophagy, decreases beclin 1 expression and triggers a switch from a survival process to cell death.
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