期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 32, 期 5, 页码 699-704出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-015-0466-6
关键词
8-EPI (8-iso Prostaglandin F-2 alpha); 8-OHdG (8-hydroxy-2 '-deoxyguanosine); ART (assisted reproductive technique); Infertility; OxS (oxidative stress); ROS (reactive oxygen species)
资金
- Enterprise Estonia [EU 30020]
- Estonian Ministry of Education and Research [SF0180132s08, IUT 20-42, IUT 15-19]
- Estonian Ministry of Education and Research (Scientific Collection Financing KOGU-HUMB)
- University of Tartu [SARMBARENG]
Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART). Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded. Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner's state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97,8 +/- 16,7 vs 72.9 +/- 22,9, p = 0.007; in men, 89.6 +/- 20,4 vs 72,1 +/- 22,6, p = 0.049). To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility.
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