期刊
AUTOPHAGY
卷 5, 期 4, 页码 578-579出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5.4.8367
关键词
HPV16 E6/E7 oncoproteins; autophagy; metabolic stress; mTOR; p53; trophic sentinel pathway; cervical cancer
类别
资金
- PHS [R01CA081135]
- [T32CA00903]
Normal human epithelial cells that express the human papillomavirus type 16 (HPV16) E7 oncoprotein show evidence of autophagy, and when deprived of growth factors they undergo cell death. We hypothesize that the process of autophagy renders such cells particularly vulnerable to cell death and suggest that autophagy induced as a consequence of uncontrolled proliferation and changes in metabolism may represent an Achilles' heel of human cancers and serve as a target for cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据