期刊
AUTOPHAGY
卷 5, 期 6, 页码 847-849出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.8824
关键词
autophagy; aging; chronological life span; rapamycin; Saccharomyces cerevisiae
类别
资金
- NIH [AG023719]
Rapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes, including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin extend yeast chronological life span (CLS). We have recently shown that autophagy is required for chronological longevity in yeast, which is attributable in part to a role for autophagy in amino acid homeostasis. We report herein that low concentrations of rapamycin stimulate macroautophagy during chronological aging and extend CLS.
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