期刊
AUTOPHAGY
卷 5, 期 5, 页码 706-708出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.5.5.8505
关键词
autophagy; mitochondria; Pink1; E3 ligase; ubiquitin; Park2; Park6
类别
资金
- NIH
- JSPS
Knockout of the ubiquitin ligase Parkin, the gene product of the Parkinson associated Park2, leads to loss of mitochondrial integrity and function in Drosophila melanogaster. Although Parkin is primarily cytosolic, we have found that Parkin is selectively recruited to dysfunctional mitochondria with low membrane potential and subsequently promotes their autophagy. Here we report that Parkin recruitment is voltage-dependent and independent of changes in ATP or pH. These findings suggest that Parkin promotes mitophagy of dysfunctional mitochondria following loss of mitochondrial membrane potential and implicates the targeted elimination of mitochondria in the pathogenesis of Parkinson disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据