期刊
AUTOPHAGY
卷 5, 期 1, 页码 100-102出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5.1.7264
关键词
Vibrio parahaemolyticus; type III secretion; infection; cell death; autophagy; apoptosis; proinflammatory
类别
资金
- NIH-AID [R01-AI056404]
- Welch Research Foundation [I-1561]
Vibrio parahaemolyticus (V. parahaemolyticus) is a gram-negative halophillic bacterium that causes worldwide seafood-borne gastroenteritis. The prevalence of V. parahaemolyticus in the environment and incidence of infection have been linked to rising water temperatures caused by global warming. Among its virulence factors, V parahaemolyticus harbors two type III secretion systems (T3SS). Recently, we have shown that T3SS I induces rapid cellular death that initiates with acute autophagy, as measured by LC3 lipidation and accumulation of early autophagosomal vesicles. While not the first characterized pathogen to usurp autophagy, this is the first example of an extracellular pathogen that exploits this pathway for its own benefit. Here we discuss possible roles for the induction of autophagy during infection and discuss how V parahaemolyticus-induced autophagy provides insight into key regulatory steps that govern the decision between apoptosis and autophagy.
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