期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 3, 期 6, 页码 528-533出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc010039f
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This paper reports some of the advantages and limitations of solid-supported liquid-liquid extraction (SLE) for the rapid purification of organic compound libraries. Issues of solvent compatibility, compound compatibility, and technical methods are addressed. In addition the prospective use of calculated log P values is investigated to determine which impurities will be effectively removed by this technique. In addition SLE is shown to be complementary and in some cases superior to solid-phase extraction (SPE) methods for library purification. This is especially true when the desired products have functionality equivalent to that of the impurity to be removed.
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