期刊
AUTOPHAGY
卷 5, 期 4, 页码 573-575出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5.4.8312
关键词
ubiquilin; PLIC; ubiquitin-like; autophagy; autophagosomes; mitophagy; lysosomes; LC3
类别
Ubiquilins (UBQLN), a family of adaptor proteins with partial homology with ubiquitin, are proposed to facilitate proteasomal degradation of ubiquitinated substrates. We now demonstrate a novel role for UBQLN in promoting autophagosome maturation during nutrient deprivation. Ectopic expression of UBQLN protects cells against starvation-induced cell death, while depletion renders cells more susceptible. This protective function requires the essential autophagy regulators, Atg5 and Atg7. The ubiquitin-associated (UBA) domain of UBQLN is required for its association with autophagosomes as well as for its prosurvival functions. Remarkably, during starvation-induced autophagy, UBQLN promotes the fusion of early autophagosomes with lysosomes. Overall, this work illustrates an important function, for UBQLN in cell survival during nutrient starvation, which requires a newly recognized function for UBQLN in autophagosome maturation.
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