期刊
AUTOPHAGY
卷 5, 期 6, 页码 858-859出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.8822
关键词
p65/RelA; autophagosomes; T lymphocytes; beclin 1; promoter; transcription; T cell receptor
类别
资金
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
We unveiled novel p65/RelA consensus sites in the promoter of the beclin 1 gene and demonstrate that p65/RelA positively modulates canonical autophagy in various human cell lines both under basal conditions and upon induction by ceramide. Interestingly, we find that T cell receptor-dependent activation of Jurkat cells triggers an increase in the binding of p65/RelA to the beclin I promoter accompanied by enhanced autophagy, suggesting that p65/RelA could regulate T-cell activation and homeostasis through autophagy.
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