期刊
AUTOPHAGY
卷 4, 期 3, 页码 359-360出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5575
关键词
autophagy; cell death; Atg; caspase; Drosophila
类别
资金
- NIGMS NIH HHS [R01 GM079431, R56 GM059136, R01 GM059136-09, R01 GM079431-04, R01 GM059136, GM079431, GM059136] Funding Source: Medline
Autophagic cell death is a prominent morphological form of cell death that occurs in diverse animals. Autophagosomes are abundant during autophagic cell death, yet the functional role of autophagy in cell death has been enigmatic. We find that autophagy and the Atg genes are required for autophagic cell death of Drosophila salivary glands. Although caspases are present in dying salivary glands, autophagy is required for complete cell degradation. Further, induction of high levels of autophagy results in caspase-independent autophagic cell death. Our results provide the first in vivo evidence that autophagy and the Atg genes are required for autophagic cell death and confirm that autophagic cell death is a physiological death program that occurs during development.
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