期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 194, 期 9, 页码 1253-1261出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.194.9.1253
关键词
T cell receptor repertoire; T cell responsiveness; CD5; MHC contact; p56(lck)
T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs. Here we show that pMHC contact modulates the expression of CD5 by naive CD4 T cells in a process that requires the continued expression of p56(lck). Reduced CD5 levels in T cells deprived of pMHC contact are predictive of elevated Ca2+ responses to subsequent TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact may be important for regulating naive CD4 T cell responsiveness.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据