期刊
NEUROSCIENCE LETTERS
卷 313, 期 3, 页码 125-128出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(01)02270-4
关键词
narcolepsy; hypocretin; orexin; histamine; dopamine; norepinephrine
资金
- NIMH NIH HHS [MH01600] Funding Source: Medline
- NINDS NIH HHS [NS23724, NS 27710] Funding Source: Medline
A growing amount of evidence suggests that a deficiency in hypocretin/orexin neurotransmission is critically involved in animal and human forms of narcolepsy. Since hypocretin-containing neurons innervate and excite histaminergic tuberomammillary neurons, altered histaminergic neurotransmission may also be involved in narcolepsy. We found a significant decrease in histamine content in the cortex and thalamus, two structures important for histamine-mediated cortical arousal, in Hcrtr-2 mutated narcoleptic Dobermans. In contrast, dopamine and norepinephrine contents in these structures were elevated in narcoleptic animals, a finding consistent with our hypothesis of altered catecholaminergic transmission in these animals. Considering the fact that histamine promotes wakefulness, decreases in histaminergic neurotransmission may also account for the sleep abnormalities in hypocretin-deficient narcolepsy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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