期刊
JOURNAL OF CELL BIOLOGY
卷 155, 期 4, 页码 649-659出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200108080
关键词
macropinocytosis; phagocytosis; apoptotic cells; phosphatidylserine; phosphatidylserine receptor
类别
资金
- NIGMS NIH HHS [GM61031, R01 GM061031, GM60449] Funding Source: Medline
Efficient phagocytosis of apoptotic cells is important for normal tissue development, homeostasis, and the resolution of inflammation. Although many receptors have been implicated in the clearance of apoptotic cells, the roles of these receptors in the engulfment process have not been well defined. We developed a novel system to distinguish between receptors involved in tethering of apoptotic cells versus those inducing their uptake. Our results suggest that regardless of the receptors engaged on the phagocyte, ingestion does not occur in the absence of phosphaticlylserine (PS). Further, recognition of PS was found to be dependent on the presence of the PS receptor (PSR). Both PS and anti-PSR antibodies stimulated membrane ruffling, vesicle formation, and bystander uptake of cells bound to the surface of the phagocyte. We propose that the phagocytosis of apoptotic cells requires two events: tethering followed by PS-stimulated, PSR-mediated macropinocytosis.
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