[GRAPHICS] The butane-2,3-diacetal (BDA) desymmetrized glycolic acid building block undergoes efficient and highly diastereoselective lithium enolate Michael additions to alpha,beta -unsaturated ketones, lactones, and nitro olefins. Subsequent deprotection of these Michael adducts gives a-hydroxy acids in very high yield. Hydrogenation of the nitro group in some of the adducts leads to gamma -lactams, which can be easily converted into alpha -hydroxy-gamma -amino acid derivatives.
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