期刊
RESPIRATION PHYSIOLOGY
卷 128, 期 3, 页码 331-348出版社
ELSEVIER
DOI: 10.1016/S0034-5687(01)00310-3
关键词
channels, ion, conductivity; enzyme, NADPH oxidase, cytochrome aa3; hypoxia, sensor; oxygen, reactive species; sensors, oxygen
NADPH oxidase isoforms with different gp91phox subunits as well as an unusual cytochrome aa3 with a heme a/a3 relationship of 9:91 are discussed as putative oxygen sensor proteins influencing gene expression and ion channel conductivity. Reactive oxygen species (ROS) are important second messengers of the oxygen sensing signal cascade determining the stability of transcription factors or the gating of ion channels. The formation of ROS by a perinuclear Fenton reaction is imaged by 1 and 2 photon confocal microscopy revealing mitochondrial and non-mitochondrial generation. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据