期刊
NEUROREPORT
卷 12, 期 16, 页码 3549-3552出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200111160-00035
关键词
accumbens; binge; D-1; dopamine; glucose; opioid; mu; rat; receptor; sugar
资金
- NIDA NIH HHS [DA-10608] Funding Source: Medline
- NINDS NIH HHS [NS-30697] Funding Source: Medline
Palatable food stimulates neural systems implicated in drug dependence; thus sugar might have effects like a drug of abuse. Rats were given 25% glucose solution with chow for 12h followed by 12h of food deprivation each day. They doubled their glucose intake in 10 days and developed a pattern-of excessive intake in the first hour of daily access. After 30 days, receptor binding was compared to chow-fed controls. Dopamine D-1 receptor binding increased significantly in the accumbens core and shell. In contrast, D-2 binding decreased in the dorsal striatum. Binding to dopamine transporter increased in the midbrain. Opioid mu-1 receptor binding increased significantly in the cingulate cortex, hippocampus, locus coeruleus and accumbens shell. Thus, intermittent, excessive sugar intake sensitized D-1 and mu-1 receptors much like some drugs of abuse. (C) 2001 Lippincott Williams & Wilkins.
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