期刊
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
卷 166, 期 1-2, 页码 93-95出版社
ELSEVIER
DOI: 10.1016/j.autneu.2011.09.006
关键词
Cancer cachexia; Heart rate variability; Autonomic nervous system
资金
- National Institute for Health Research [PDF-2011-04-048] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [PDF-2011-04-048] Funding Source: National Institutes of Health Research (NIHR)
- Department of Health [PDF-2011-04-048] Funding Source: Medline
Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms(2) 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components. (C) 2011 Elsevier B.V. All rights reserved.
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