期刊
TETRAHEDRON
卷 57, 期 47, 页码 9549-9554出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(01)00958-9
关键词
sphingolipid calyxoside; structure and stereochemistry; bioactivity
Bioassay-directed fractionation of a sponge of the genus Calyx using a yeast bioassay for DNA-damaging agents yielded the novel sphingolipid calyxoside (1) as the major bioactive constituent. The structure of 1 was assigned as 1,3,26-trihydroxy-2,27-diaminooctacosan-18-one-1-beta -D-glucoside by H-1- and C-13 NMR, DEPT, DQCOSY, HMQC, and HMBC spectra. The carbonyl group was located at C-18 by analysis of the EI-MS fragmentation of the amino derivative of its aglycone pentaacetate. Its absolute configuration was determined as 2S,3R,26S,27S by analysis of the H-1 NMR and CD spectra of its aglycone pentabenzoate. (C) 2001 Published by Elsevier Science Ltd.
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