Approaches to selective DNA binding in polyfunctional dinuclear platinum chemistry.: The synthesis of a trifunctional compound and its interaction with the mononucleotide 5′-guanosine monophosphate

The introduction of the malonate ligand as a leaving group in trifunctional dinuclear platinum complexes allows stepwise binding modes to be controlled, as shown using a small mononucleotides such as guanosine 5'-monophosphate. Subtle changes in the metal coordination sphere can be used to produce specific and selective ternary DNA-DNA and DNA-protein interactions. [GRAPHICS]