期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 52, 期 3, 页码 177-186出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-409X(01)00214-9
关键词
fusogenic liposome; Sendai virus; tumor vaccine; mucosal vaccine; cancer chemotherapy; gene therapy
We prepared fusogenic liposomes by fusing conventional liposomes with an ultra-violet inactivated Sendai virus. Fusogenic liposomes can deliver encapsulated contents into the cytoplasm directly in a Sendai virus fusion-dependent manner. Based on the high delivery rates into the cytoplasm, we originally planned to apply the fusogenic liposomes to cancer chemotherapy and gene therapy. We have recently also examined the use of fusogenic liposomes as an antigen delivery vehicle. In terms of vaccine development, cytoplasmic delivery is crucial for the induction of the cytotoxic T lymphocyte (CTL) responses that play a pivotal role against infectious diseases and cancer. In this context, our recent studies suggested that fusogenic liposomes could deliver encapsulated antigens into the cytoplasm and induce MHC class I-restricted, antigen-specific CTL responses. In addition, fusogenic liposomes are also effective as a mucosal vaccine carrier. In this review, we present the feasibility of fusogenic liposomes as a versatile and effective antigen delivery system. (C) 2001 Elsevier Science B.V. All rights reserved.
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