4.5 Article

N-propargyl-2-alkynylbenzothiazolium aza-enediynes:: Role of the 2-alkynylbenzothiazolium functionality in DNA cleavage

期刊

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 11, 期 22, 页码 2971-2974

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00606-0

关键词

-

向作者/读者索取更多资源

The 2-alkynylbenzothiazolium salts 3a-d incorporating an N-propargyl moiety have been prepared as aza-enediyne analogues. While these aza-enediynes are shown to be modest DNA cleavage agents, DNA cleavage was also observed with the N-methyl-2-alkynylbenzothiazolium salt 4, which lacks the aza-enediyne moiety. The structural requirements for DNA cleavage, and the correlation of DNA cleavage efficiency with the propensity of these compounds to undergo nucleophilic addition by methanol support a proposed DNA cleavage mechanism involving DNA alkylation. by appropriate 2-alkynyl-substituted benzothiazolium salts. (C) 2001 Elsevier Science Ltd. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据