期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 17, 期 5, 页码 541-549出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2015.1043900
关键词
Nidulariaceae; NO inhibition; cytotoxicity; cyathane diterpenoids; Cyathus africanus
资金
- China Ocean Mineral Resources RD Association [DY125-15-T-07]
- National Natural Science Foundation of China [21472233, 81473119, 81473590, 81274115, 81102343]
- China-Japan Friendship Hospital Youth Science and Technology Excellence Project [2014-QNYC-B-10, 2013-MS-34]
- Program for New Century Excellent Talents in University of the Chinese Ministry of Education [NCET-11-0606]
- Program for Excellent Talents of Beijing Municipal Party Committee Organization Department of the Communist Party of China [2013D009999000001]
Three new cyathane diterpenoids, cyathin W (1), cyathin V (2), and cyathin T (3), were isolated from the solid culture of Cyathus africanus. The structures and configurations of these new compounds were elucidated on the basis of comprehensive spectroscopic analysis including 1D NMR, 2D NMR (HSQC, HMBC, NOESY), and HR-ESI-MS experiments. Compounds 1 and 3 showed moderate inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with IC50 value of 80.07 and 88.87 mu M, respectively. In cytotoxicity assay, compound 1 showed weak cytotoxicity against K562 cell line with IC50 value of 12.1 mu M.
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