期刊
ONCOGENE
卷 20, 期 54, 页码 7888-7898出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204860
关键词
viral oncoproteins; papillomaviruses; p53; retinoblastoma; tumor suppressor; centrosomes
资金
- NCI NIH HHS [R01 CA81135, R01 CA66980] Funding Source: Medline
- NIDCR NIH HHS [P01 DE12467, K16 DE00275] Funding Source: Medline
The human papillomavirus (HPV) E7 protein is one of only two viral proteins that remain expressed in HPV-associated human cancers. HPV E7 proteins share structural and functional similarities with oncoproteins encoded by other small DNA tumor viruses such as adenovirus EIA and SV40 large tumor antigen. The HPV E7 protein plays an important role in the viral life cycle by subverting the tight link between cellular differentiation and proliferation in normal epithelium, thus allowing the virus to replicate in differentiating epithelial cells that would have normally withdrawn from the cell division cycle. The transforming activities of E7 largely reflect this important function.
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