期刊
DEVELOPMENTAL BRAIN RESEARCH
卷 131, 期 1-2, 页码 149-152出版社
ELSEVIER
DOI: 10.1016/S0165-3806(01)00264-4
关键词
neuropeptide Y; maternal separation; depression; brain; trait marker
资金
- NCRR NIH HHS [M01 RR000833] Funding Source: Medline
- NIAAA NIH HHS [AA 006902, P50 AA007611, K05 AA 00223, R01 AA010201, AA 06059] Funding Source: Medline
Human and animal studies support the involvement of neuropeptide Y (NTY) in the pathophysiology of depression. Thus, hippocampal NPY-LI is decreased in genetic models of depression, the Flinders Sensitive Line and Fawn Hooded rats. Maternal 'deprivation' has been identified as one risk factor in the development of psychopathology, including depression in adulthood. In view of these findings we hypothesized that brain NTY may also be decreased in an animal model of early life maternal deprivation. To test this hypothesis, male and female Sprague-Dawley rats were maternally separated (MS) 6 h/day or briefly handled from postnatal day 2 (PN2) to PN6 and from PN9 to PN13. At 12 weeks of age the rats were sacrificed, the brains dissected and NPY-Ll measured by radioimmunoassay. MS rats had lower NTY-LI in the hippocampus. NPY-LI was also lower in female compared to male rats in hippocampus. Lastly, NTY-LI was increased in the hypothalamus of both male and female MS rats. These findings support the hypothesis that altered NPY in the limbic re.-ion is a common denominator of several models of depression and might be a trait marker of vulnerability to affective disorders. (C) 2001 Elsevier Science B.V. All rights reserved.
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